The Coastal Plain League announced 12 players, both former and players signed for the 1998 season, were drafted in the 1998 Major League Baseball First-Year Player Draft. The complete list of CPL players drafted follows:
| Round | Overall | Player | College/University | MLB Team Drafted By | CPL Team(s) |
|---|---|---|---|---|---|
| 12 | 363 | Donnie Suttles | Western Carolina | Cleveland | ’97 Rocky Mount |
| 14 | 414 | Kevin Hook | Loyola-Marymount | Montreal | ’97 Durham |
| 14 | 415 | Matt Phillips | Delaware | Boston | ’97 Wilmington |
| 17 | 514 | Ty Wigginton | New York (NL) | UNC Asheville | ’97 Rocky Mount / ’98 Florence |
| 19 | 565 | Shon Norris | UNC Asheville | Boston | ’97 Rocky Mount / ’98 Florence |
| 20 | 596 | Jeff Becker | Duke | Milwaukee | ’97 Durham |
| 20 | 611 | Gregg Maluchnik | Duke | Atlanta | ’97 Raleigh |
| 25 | 759 | Joey Hammond | Charlotte | Baltimore | ’97 Wilson |
| 27 | 821 | Allen Scarce | NC State | Atlanta | ’97 Wilmington |
| 30 | 884 | Kurt Blackmon | NC State | Philadelphia | ’97 Raleigh |
| 42 | 1272 | Jody Fuller | Tennessee-Martin | Arizona | ’97 Durham |
| 48 | 1401 | Chris Curry | Meridian JC | Detroit | ’97 Outer Banks |